Synthesis of aspirin (acetylsalicylic acid) place 20 g (0015 mole) of salicylic acid in a 125-ml erlenmeyer flask add 5 ml (005 mole) of acetic anhydride, followed by 5 drops of conc h 2 so 4 (use a dropper, h 2 so 4 is highly corrosive) and swirl the flask gently until the salicylic acid dissolves. Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a pain killer salicylic acid, whose name comes from salix , the willow family of plants, was derived from. Aspirin is the most widely used over-the-counter drug in the world the average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid with an inert binding material such as starch. The synthesis of aspirin chemistry standard level lab report data collection and processing and conclusion and evaluation date: december 8th, 2011 purpose: the purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by adding iron (iii.
Aspirin has been used as a medicine by the ancient greeks and the pharaohs of egypt it is effective in reducing pain (it is an analgesic), reducing inflammation (anti-inflammatory), reducing fever (antipyretic), and thinning blood (anti-coagulant. Background principle: synthesis of aspirin from salicylic acid occurs by acetylation process in acidic medium salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid.
Carbon introduction aspirin is a pain relieving compound that most students will be familiar with, thus its synthesis gives students an insight into how chemistry. Aspirin (2nd edition) compiled by david lewis edited by colin osborne and maria pack designed by imogen bertin and sara roberts first published by the royal society of chemistry in 1998.
Aspirin, also known as acetylsalicylic acid (asa), is a medication used to treat pain, fever, or inflammation specific inflammatory conditions in which aspirin is used include kawasaki disease, pericarditis, and rheumatic fever. Abstract: the synthesis of aspirin is a part of many undergraduate organic synthesis labs and is frequently used in qualitative organic analysis laboratory for the identification of salicylic acid we have found that aspirin can be synthesized on microscale by a. The synthesis and analysis of aspirin mariam el-magbri department of chemistry, american university, washington, dc 20016 date of publication: february 26, 2014.
Synthesis of aspirin in this experiment, aspirin will be made by the esterification of salicylic acid the product will be isolated and a thin layer chromatography (tlc) will. Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker the temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water the temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Aspirin, the name being derived from a for acetyl, and the root -spir, from the latin name spiraea ulmaria , the meadow sweet flower, from which salicylic acid had been isolated in this experiment, le chȃtelier's principle and esterification of the phenolic hydroxyl group of. The synthesis of aspirin chemistry standard level lab report data collection and processing and conclusion and evaluation date: december 8th, 2011 purpose: the purpose of this lab was to synthesize aspirin, determine the theoretical yield, compare the percent yield to the theoretical yield and test the purity of aspirin by adding iron (iii) chloride to the product. Aspirin is one of the most commonly used drugs in the world with approximately 100 billion tablets 1 being consumed annually salicylic acid is a precursor of aspirin.
Synthesis of aspirin salicylic acid derivatives, or salicin, are found in the bark of the willow tree in the 5th century bc, hippocrates ground the bark into a powder, and later, the natives americans chewed on the bark to alleviate fever and pain1. The chemical equation for the synthesis of aspirin is c7h6o3 + c4h6o3 - c9h8o4 +c2h4o2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. Store the aspirin in the desi-cooler and determine the percent yield of the synthesis by taking the actual yield and dividing it by the theoretical yield, determined from the original amount of salicylic acid used. Organic synthesis is the process where a desired organic compound is constructed or prepared from commercially available materials the objective of organic synthesis is to design the simplest synthetic routes to a molecule.
Aspirin to diminish inflammation is due to its inhibition of the synthesis of prostaglandins aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group 4. Exercise 11 synthesis of aspirin (acetylsalicylic acid from salicylic acid) sharmaine s bungabong group 2 5l i introduction organic synthesis is an important aspect in the industry of organic chemistry this aspect of organic chemistry has contributed much to the knowledge there is regarding the. A useful synthesis of acetylsalicylic acid was developed in 1893, patented in 1899, marketed under the trade name of aspirin by the bayer company in germany the name aspirin was invented by the chemist, felix.
42 experiment 8 - synthesis of aspirin aspirin is an effective analgesic (pain reliever), antipyretic (fever reducer) and anti-inflammatory agent and is one of the most widely used non-prescription drugs. Synthesis and analysis of aspirin lab adv comp 22 from advanced chemistry with vernier, vernier software & technology, 2004 introduction aspirin, the ubiquitous pain reliever, goes by the chemical name acetylsalicylic acid. The main objective of the synthesis of aspirin lab was so produce aspirin (acetylsalicylic acid) through the reaction of salicylic acid and acetic anhydride the methods used included recrystallization and scratching to produce a precipitate, which was then filtered to remove any excess moisture.